Editorial: Sortilin and Sortilin Partners in Physiology and Pathologies

Sortilin and atherosclerosis

The complexity and intricacy of nature has recently been illustrated with the role of sortilin in atherosclerosis. Sortilin, a VPS10p sorting receptor initially identified in human brain tissue, suddenly gained much attention from the cardiovascular community as unbiased genome-wide association studies (GWASs) repeatedly demonstrated that single nucleotide polymorphisms (SNPs) at the 1p13.3 loc...

Pro-neurotrophins, sortilin, and nociception

Nerve growth factor (NGF) signaling is important in the development and functional maintenance of nociceptors, but it also plays a central role in initiating and sustaining heat and mechanical hyperalgesia following inflammation. NGF signaling in pain has traditionally been thought of as primarily engaging the classic high-affinity receptor tyrosine kinase receptor TrkA to initiate sensitizatio...

SORTILIN: many headed hydra.

Sorting out sortilin.

G association studies have the potential to lead to identification of novel pathways and mechanisms for the pathogenesis of common complex diseases. Previous genome-wide association studies have identified a locus on 1p13 as a risk locus for dyslipidemia and myocardial infarction. However, the responsible mechanisms have remained elusive. Two recent reports implicate SORT1 as the causative gene...

Sortilin and the risk of cardiovascular disease.

Plasma low-density lipoprotein cholesterol (LDL-C) levels are a key determinant of the risk of cardiovascular disease, which is why many studies have attempted to elucidate the pathways that regulate its metabolism. Novel latest-generation sequencing techniques have identified a strong association between the 1p13 locus and the risk of cardiovascular disease caused by changes in plasma LDL-C le...